Human papilloma resembles that of tongue cancer and its symptoms. In the recent years, the human papilloma viral infection of the oral cavity and oropharyngeal region has increased. The infections are believed to lead to tongue cancer.
The human papilloma virus is a known causative factor for cervical cancer. This virus is also implicated in male and female genital cancers, and anal cancers. The oral spread of the virus occurs through the unsafe genital-oral sexual practices and having multiple partners, and other mechanisms, such as kissing.
The human papilloma virus expresses a protein called E6/E7, which transforms a normal cell into a cancer cell with unlimited proliferation capacity. Paradoxically, the human papilloma virus, while being one of the causative factors for tongue cancer, is also a marker that predicts a good response to chemotherapy.
A study done by doctors a few years ago from the Comprehensive Cancer Center of the University of Michigan in Ann Arbor conducted a study to study the differences in oral cavities between those infected with the virus and those unaffected. Upon understanding their results, they learned some had the virus, while others did not. The patients with the virus in their tongue biopsy samples responded beautifully to the chemotherapy treatments. These same patients did not undergo surgery and were more likely to survive the cancerous stage and proceed to a cancer-free state.
On the other hand, patients whose tongue biopsy samples were negative for the human papilloma virus did not respond to chemotherapy. These patients had to undergo complicated surgical procedures, and many of these patients did not survive the cancer. While the survival rate for the patients who were positive for the human papilloma virus was 78%, it was only 36% among the patients who did not score positive for the human papilloma virus in their oral cavity.
Ever since the discovery of a difference between the survival rates of the tongue cancer patients based on the human papilloma viral infection, the researchers have looked for reasons. One of the reasons is that the tumor cells of those patients, who do not have the human papilloma viral infection, instead have some of the most powerful cancer promoting agents in their tumor cells. These agents include the Epidermal Growth Factor Receptor (EGFR) and the Vascular Endothelial Growth Factor (VEGF).
Both growth factors grow at fast and aggressive rates. Cigarette smoke and carcinogens increase the cell size. Blood vessels increase in size, creating an enlarged tumor and spread to nearby organs. With these staggering results, it is no wonder the University of Michigan received such shocking results.
Recently, several biotech companies developed specific drugs to target the agents (EGFR and VEGF), in turn providing reassuring news for tongue cancer sufferers. With this information, please learn to become aware of the link between human papilloma and tongue cancer symptoms.
The human papilloma virus is a known causative factor for cervical cancer. This virus is also implicated in male and female genital cancers, and anal cancers. The oral spread of the virus occurs through the unsafe genital-oral sexual practices and having multiple partners, and other mechanisms, such as kissing.
The human papilloma virus expresses a protein called E6/E7, which transforms a normal cell into a cancer cell with unlimited proliferation capacity. Paradoxically, the human papilloma virus, while being one of the causative factors for tongue cancer, is also a marker that predicts a good response to chemotherapy.
A study done by doctors a few years ago from the Comprehensive Cancer Center of the University of Michigan in Ann Arbor conducted a study to study the differences in oral cavities between those infected with the virus and those unaffected. Upon understanding their results, they learned some had the virus, while others did not. The patients with the virus in their tongue biopsy samples responded beautifully to the chemotherapy treatments. These same patients did not undergo surgery and were more likely to survive the cancerous stage and proceed to a cancer-free state.
On the other hand, patients whose tongue biopsy samples were negative for the human papilloma virus did not respond to chemotherapy. These patients had to undergo complicated surgical procedures, and many of these patients did not survive the cancer. While the survival rate for the patients who were positive for the human papilloma virus was 78%, it was only 36% among the patients who did not score positive for the human papilloma virus in their oral cavity.
Ever since the discovery of a difference between the survival rates of the tongue cancer patients based on the human papilloma viral infection, the researchers have looked for reasons. One of the reasons is that the tumor cells of those patients, who do not have the human papilloma viral infection, instead have some of the most powerful cancer promoting agents in their tumor cells. These agents include the Epidermal Growth Factor Receptor (EGFR) and the Vascular Endothelial Growth Factor (VEGF).
Both growth factors grow at fast and aggressive rates. Cigarette smoke and carcinogens increase the cell size. Blood vessels increase in size, creating an enlarged tumor and spread to nearby organs. With these staggering results, it is no wonder the University of Michigan received such shocking results.
Recently, several biotech companies developed specific drugs to target the agents (EGFR and VEGF), in turn providing reassuring news for tongue cancer sufferers. With this information, please learn to become aware of the link between human papilloma and tongue cancer symptoms.
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